
Later, Thomas formed the Big Tymers along with Williams, as Mannie Fresh and Birdman respectively, bringing him fame, and released five albums. He also produced all tracks on the members' solo works as well. With Williams' help, Thomas made chart-topping albums for the Hot Boys, which was composed of Lil Wayne, B.G., Juvenile, and Turk, producing all of the group's albums.

After their last album together, in 1993, Thomas met Bryan "Baby" Williams, who gave him an opportunity to become the in-house producer of his record label Cash Money Records. They would release two more records together in the late 1980s and early 1990s.

They released their first album together Throwdown in 1987, with Mannie Fresh producing and MC Gregory D rapping. In the late 1980s, he began a partnership with New Orleans rapper MC Gregory D. Influenced by his father DJ Sabu, Thomas became a DJ for New Orleans hip hop crew New York Incorporated in 1984 at age 15. Thomas was born and raised in the 7th Ward of New Orleans. He also was their only in-house producer when the company started in 1991. He produced all or most of the songs on 17 multi-platinum, platinum or gold albums for Cash Money from 1998 to 2004 before leaving the label. He's best known for his productions on Cash Money Records releases, as well being half of the hip hop duo (alongside label co-founder Birdman) the Big Tymers. Byron Otto Thomas (born March 20, 1969), better known by his stage name Mannie Fresh, is an American record producer, DJ and rapper.
